Thomas Edison on a Studebaker Electric (1903). Studebaker was the only car company to make the transition from building wagons and horse-carriages to automobiles. Studebaker made electric cars from 1903-1911 before turning to gas engines.
In 1932, Dr. Archibald Purves from England designed the Dynasphere. He believed that one huge wheel encompassing five passengers was far more efficient than a car with four wheels. The biggest issue was that it steered quite poorly.