"the blood thinning requirement is greater for homozygous individuals"  to anti-coagulate blood- get the Homocysteine level down to between 6-7. taking 81 mg Aspirin a day is also a good idea along with staying well hydrated and taking omega #3 krill oil and cod liver oil, and Vitamin E. Mthfr A1298c, Methylation, Mthfr Gene Mutation, Methylfolate, Depression Medication, Thing 1, Dna Test, Intolerance, Glutathione